WHAT IT DOES?
Aplasys computational platform will analyze a wide range of possibilities like individual tRNAs and ribosome abundance and provide you with the detailed recommendation on what you can improve in your expression system or which expression host will express your protein with the highest yield.
It is well known that protein expression host may go through different stages that critically affect the protein expression levels. Also, your coding sequence may have dramatically different performance in different host strains or different cell-free systems. Among the factors that we analyze are ribosome abundance, initiation and termination factors besides the EF-IV (LepA) and ribosome translocation error rates. Comparative evaluation of the protein expression yield using purely laboratory protocols is a Herculean task. Aplasys offers the service based on our advanced computational platform that can save you numerous trail-and-error cycles required to identify the best environment to synthesize your protein.